LRP12 silencing during brain development results in cortical dyslamination and seizure sensitization

LRP12 silencing during brain development results in cortical dyslamination and seizure sensitization

Correct positioning and differentiation of neurons during brain development is a key precondition for proper function. Focal cortical dysplasias (FCDs) are increasingly recognized as causes of therapy refractory epilepsies. Neuropathological analyses of respective surgical specimens from neurosurger...

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Bibliographic Details
Main Authors: Alexander Grote, Barbara K. Robens, Ingmar Blümcke, Albert J. Becker, Susanne Schoch, Eva Gembé
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Neurobiology of Disease
Subjects:
Malformation
Migration
In utero electroporation
Differentiation
Epilepsy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996115300991

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