Evaluation of the In Vitro Damage Caused by Lipid Factors on Stem Cells from a Female Rat Model of Type 2 Diabetes/Obesity and Stress Urinary Incontinence

Evaluation of the In Vitro Damage Caused by Lipid Factors on Stem Cells from a Female Rat Model of Type 2 Diabetes/Obesity and Stress Urinary Incontinence

Human stem cell therapy for type 2 diabetes/obesity (T2D/O) complications is performed<br />with stem cell autografts, exposed to the noxious T2D/O milieu, often with suboptimal results.<br />We showed in the Obese Zucker (OZ) rat model of T2D/O that when their muscle-derived stem<br...

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Bibliographic Details
Main Authors: Istvan Kovanecz, Robert Gelfand, Sheila Sharifzad, Alec Ohanian, William Brent DeCastro, Carley Cooper, Guiting Lin, Tom Lue, Nestor F. Gonzalez-Cadavid
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
stem cell damage
muscle-derived stem cells
dyslipidemia
cholesterol
palmitic acid
free fatty acids
Online Access:https://www.mdpi.com/1422-0067/21/14/5045

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