The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells

The 1,4 benzoquinone-featured 5-lipoxygenase inhibitor RF-Id induces apoptotic death through downregulation of IAPs in human glioblastoma cells

Abstract Background Embelin is a potent dual inhibitor of 5-lipoxigenase (5-LOX) and microsomal prostaglandin E2 synthase (mPGES)-1 that suppresses proliferation of human glioma cells and induces apoptosis by inhibiting XIAP and NF-κB signaling pathway. Synthetic structural modification yielded the...

Full description

Bibliographic Details
Main Authors: S. Zappavigna, M. Scuotto, A. M. Cossu, D. Ingrosso, M. De Rosa, C. Schiraldi, R. Filosa, M. Caraglia
Format: Article
Language:English
Published: BMC 2016-10-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Apoptosis
Glioblastoma
IAPs
NFκB
RF-Id
Online Access:http://link.springer.com/article/10.1186/s13046-016-0440-x

Internet

http://link.springer.com/article/10.1186/s13046-016-0440-x

Similar Items