A novel multiplex qPCR assay for detection of Plasmodium falciparum with histidine-rich protein 2 and 3 (pfhrp2 and pfhrp3) deletions in polyclonal infections

A novel multiplex qPCR assay for detection of Plasmodium falciparum with histidine-rich protein 2 and 3 (pfhrp2 and pfhrp3) deletions in polyclonal infections

Background: Many health facilities in malaria endemic countries are dependent on Rapid diagnostic tests (RDTs) for diagnosis and some National Health Service (NHS) hospitals without expert microscopists rely on them for diagnosis out of hours. The emergence of P. falciparum lacking the gene encoding...

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Bibliographic Details
Main Authors: Lynn Grignard, Debbie Nolder, Nuno Sepúlveda, Araia Berhane, Selam Mihreteab, Robert Kaaya, Jody Phelan, Kara Moser, Donelly A. van Schalkwyk, Susana Campino, Jonathan B. Parr, Jonathan J. Juliano, Peter Chiodini, Jane Cunningham, Colin J. Sutherland, Chris Drakeley, Khalid B. Beshir
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:EBioMedicine
Subjects:
pfhrp2
pfldh
qPCR
RDT
Malaria
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396420301328

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