Femoral non-union above a fused knee: Successful treatment with exchange nailing and intramedullary delivery of bone morphogenetic protein

Bone healing is a complex and well-orchestrated physiological process, in which bone repairs and regenerates regaining its original biomechanical and biochemical properties. It is estimated that 5 to 10% of all fractures are complicated by delayed union or non-union. Progression to non-union is thou...

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Main Authors:	Marilena Giannoudi, Michalis Panteli, Emmanuele Santolini, Peter V. Giannoudis
Format:	Article
Language:	English
Published:	Elsevier 2020-02-01
Series:	Trauma Case Reports
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352644019301104

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spelling	doaj-5e6714e2c5184332b7ef13aa03cb5e4f2020-11-25T00:55:07ZengElsevierTrauma Case Reports2352-64402020-02-0125Femoral non-union above a fused knee: Successful treatment with exchange nailing and intramedullary delivery of bone morphogenetic proteinMarilena Giannoudi0Michalis Panteli1Emmanuele Santolini2Peter V. Giannoudis3Academic Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, Leeds, United KingdomAcademic Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, Leeds, United Kingdom; Corresponding author at: Academic Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, Clarendon Wing, Level A, Great George Street, Leeds LS1 3EX, West Yorkshire, United Kingdom.Academic Unit of Trauma and Orthopaedics, University of Genoa, Ospedale Policlinico San Martino, Genoa, ItalyAcademic Department of Trauma & Orthopaedics, School of Medicine, University of Leeds, Leeds, United Kingdom; NIHR Leeds Biomedical Research Unit, Chapel Allerton Hospital, Leeds, United KingdomBone healing is a complex and well-orchestrated physiological process, in which bone repairs and regenerates regaining its original biomechanical and biochemical properties. It is estimated that 5 to 10% of all fractures are complicated by delayed union or non-union. Progression to non-union is thought to be multifactorial, even though the exact biological sequence remains obscure.Treatment should aim to addressing deficiencies in both the mechanical and biological components, along with eliminating co-factors that could negatively affect the locally induced fracture healing response.We report a case of a 78-year-old patient who presented with a distal femoral non-union above a previously fused knee, which was successfully managed with exchange nailing and intramedullary delivery of recombinant human bone morphogenetic protein-7 (rhBMP-7). Keywords: Femur, Non-union(s), Fused, BMP, Nailhttp://www.sciencedirect.com/science/article/pii/S2352644019301104
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Marilena Giannoudi Michalis Panteli Emmanuele Santolini Peter V. Giannoudis
spellingShingle	Marilena Giannoudi Michalis Panteli Emmanuele Santolini Peter V. Giannoudis Femoral non-union above a fused knee: Successful treatment with exchange nailing and intramedullary delivery of bone morphogenetic protein Trauma Case Reports
author_facet	Marilena Giannoudi Michalis Panteli Emmanuele Santolini Peter V. Giannoudis
author_sort	Marilena Giannoudi
title	Femoral non-union above a fused knee: Successful treatment with exchange nailing and intramedullary delivery of bone morphogenetic protein
title_short	Femoral non-union above a fused knee: Successful treatment with exchange nailing and intramedullary delivery of bone morphogenetic protein
title_full	Femoral non-union above a fused knee: Successful treatment with exchange nailing and intramedullary delivery of bone morphogenetic protein
title_fullStr	Femoral non-union above a fused knee: Successful treatment with exchange nailing and intramedullary delivery of bone morphogenetic protein
title_full_unstemmed	Femoral non-union above a fused knee: Successful treatment with exchange nailing and intramedullary delivery of bone morphogenetic protein
title_sort	femoral non-union above a fused knee: successful treatment with exchange nailing and intramedullary delivery of bone morphogenetic protein
publisher	Elsevier
series	Trauma Case Reports
issn	2352-6440
publishDate	2020-02-01
description	Bone healing is a complex and well-orchestrated physiological process, in which bone repairs and regenerates regaining its original biomechanical and biochemical properties. It is estimated that 5 to 10% of all fractures are complicated by delayed union or non-union. Progression to non-union is thought to be multifactorial, even though the exact biological sequence remains obscure.Treatment should aim to addressing deficiencies in both the mechanical and biological components, along with eliminating co-factors that could negatively affect the locally induced fracture healing response.We report a case of a 78-year-old patient who presented with a distal femoral non-union above a previously fused knee, which was successfully managed with exchange nailing and intramedullary delivery of recombinant human bone morphogenetic protein-7 (rhBMP-7). Keywords: Femur, Non-union(s), Fused, BMP, Nail
url	http://www.sciencedirect.com/science/article/pii/S2352644019301104
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Femoral non-union above a fused knee: Successful treatment with exchange nailing and intramedullary delivery of bone morphogenetic protein

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