Liver Transcriptome Dynamics During Hibernation Are Shaped by a Shifting Balance Between Transcription and RNA Stability

Liver Transcriptome Dynamics During Hibernation Are Shaped by a Shifting Balance Between Transcription and RNA Stability

Hibernators dramatically lower metabolism to save energy while fasting for months. Prolonged fasting challenges metabolic homeostasis, yet small-bodied hibernators emerge each spring ready to resume all aspects of active life, including immediate reproduction. The liver is the body’s metabolic hub,...

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Bibliographic Details
Main Authors: Austin E. Gillen, Rui Fu, Kent A. Riemondy, Jennifer Jager, Bin Fang, Mitchell A. Lazar, Sandra L. Martin
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Physiology
Subjects:
A-to-I RNA editing
ARE-binding proteins
alternative splicing
hepatocyte
Ictidomys tridecemlineatus
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.662132/full

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