Chronic persistent HHV‐6B infection after sulfasalazine‐induced DRESS with demonstration of HHV‐6 encoded small noncoding RNAs (sncRNAs) in Crohn’s‐like colitis: Case report

Chronic persistent HHV‐6B infection after sulfasalazine‐induced DRESS with demonstration of HHV‐6 encoded small noncoding RNAs (sncRNAs) in Crohn’s‐like colitis: Case report

Abstract A sulfasalazine‐induced DRESS (Drug Reactivation with Eosinophilia and Systemic Symptoms) was complicated by a Crohn's‐like colitis. We demonstrated HHV‐6 reactivation with presence of HHV‐6 DNA and small noncoding RNA in colonic lesions. This observation confirms the major role of HHV...

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Bibliographic Details
Main Authors: Vincent Descamps, Agnès Gautheret‐Dejean, Anne‐Laure Pelletier, Pascale Bonnafous, Lydia Deschamps, Bhupesh K. Prusty
Format: Article
Language:English
Published: Wiley 2021-02-01
Series:Clinical Case Reports
Subjects:
Crohn's disease
drug reaction with eosinophilia and systemic symptoms
drug‐induced hypersensitivity syndrome
human herpesvirus 6B
Online Access:https://doi.org/10.1002/ccr3.3680
Description
Summary:Abstract A sulfasalazine‐induced DRESS (Drug Reactivation with Eosinophilia and Systemic Symptoms) was complicated by a Crohn's‐like colitis. We demonstrated HHV‐6 reactivation with presence of HHV‐6 DNA and small noncoding RNA in colonic lesions. This observation confirms the major role of HHV‐6 reactivation in DRESS manifestations and the importance of looking for HHV‐6 reactivation in DRESS.
ISSN:2050-0904

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