The therapeutic potential of colchicine in the complications of COVID19. Could the immunometabolic properties of an old and cheap drug help?
The present study analyzes the importance of the inflammasome that involves the NLRP3 complex in the state of hypercytokinemia observed in patients with COVID-19, significantly increasing IL-1β, IL18, IL-6, and TNF. Unfortunately, improving the immune response can sometimes worsen the outcome of the...
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Elsevier
2020-09-01
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| Series: | Metabolism Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589936820300256 |
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doaj-5e4cf447180d4d1f850bf1bc6b654c662020-11-25T03:13:17ZengElsevierMetabolism Open2589-93682020-09-017100045The therapeutic potential of colchicine in the complications of COVID19. Could the immunometabolic properties of an old and cheap drug help?Sandro Augusto Ribeiro0Cassio Lopes1Ricardo Amaral2Adilaine Amaral3Corresponding author. Intensive Medical Assistance - AMI, Av. Rio de Janeiro, 4170, Porto Velho, Rondônia, 76820050, Brazil.; Hospital John Paul II, Intensive Medical Assistance, AMI, Porto Velho, RO, BrazilHospital John Paul II, Intensive Medical Assistance, AMI, Porto Velho, RO, BrazilMinistry of Health, Montes Claros, MG, BrazilNorthern University of Paraná, Porto Velho, BrazilThe present study analyzes the importance of the inflammasome that involves the NLRP3 complex in the state of hypercytokinemia observed in patients with COVID-19, significantly increasing IL-1β, IL18, IL-6, and TNF. Unfortunately, improving the immune response can sometimes worsen the outcome of the disease. Studies show that colchicine, among other actions, inhibits the assembly of NLRP3 complex that is responsible for generating the active form of Caspase-1 that will convert Pro-IL-1β and Pro-IL-18 into their active forms. We suggest using colchicine, a class of drugs with low-cost, extensively tested, well-tolerated medicine as a complementary treatment for patients with COVID-19, in early stages of the disease based on knowledge of its immunomodulatory properties.http://www.sciencedirect.com/science/article/pii/S2589936820300256CytokinesCovid-19Sars-Cov-2Colchicine |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Sandro Augusto Ribeiro Cassio Lopes Ricardo Amaral Adilaine Amaral |
| spellingShingle |
Sandro Augusto Ribeiro Cassio Lopes Ricardo Amaral Adilaine Amaral The therapeutic potential of colchicine in the complications of COVID19. Could the immunometabolic properties of an old and cheap drug help? Metabolism Open Cytokines Covid-19 Sars-Cov-2 Colchicine |
| author_facet |
Sandro Augusto Ribeiro Cassio Lopes Ricardo Amaral Adilaine Amaral |
| author_sort |
Sandro Augusto Ribeiro |
| title |
The therapeutic potential of colchicine in the complications of COVID19. Could the immunometabolic properties of an old and cheap drug help? |
| title_short |
The therapeutic potential of colchicine in the complications of COVID19. Could the immunometabolic properties of an old and cheap drug help? |
| title_full |
The therapeutic potential of colchicine in the complications of COVID19. Could the immunometabolic properties of an old and cheap drug help? |
| title_fullStr |
The therapeutic potential of colchicine in the complications of COVID19. Could the immunometabolic properties of an old and cheap drug help? |
| title_full_unstemmed |
The therapeutic potential of colchicine in the complications of COVID19. Could the immunometabolic properties of an old and cheap drug help? |
| title_sort |
therapeutic potential of colchicine in the complications of covid19. could the immunometabolic properties of an old and cheap drug help? |
| publisher |
Elsevier |
| series |
Metabolism Open |
| issn |
2589-9368 |
| publishDate |
2020-09-01 |
| description |
The present study analyzes the importance of the inflammasome that involves the NLRP3 complex in the state of hypercytokinemia observed in patients with COVID-19, significantly increasing IL-1β, IL18, IL-6, and TNF. Unfortunately, improving the immune response can sometimes worsen the outcome of the disease. Studies show that colchicine, among other actions, inhibits the assembly of NLRP3 complex that is responsible for generating the active form of Caspase-1 that will convert Pro-IL-1β and Pro-IL-18 into their active forms. We suggest using colchicine, a class of drugs with low-cost, extensively tested, well-tolerated medicine as a complementary treatment for patients with COVID-19, in early stages of the disease based on knowledge of its immunomodulatory properties. |
| topic |
Cytokines Covid-19 Sars-Cov-2 Colchicine |
| url |
http://www.sciencedirect.com/science/article/pii/S2589936820300256 |
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