Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapy

Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapy

A 79-year-old female was diagnosed with a right renal tumor with a level II tumor thrombus of the vena cava. presurgical therapy was initiated with a combination of avelumab and axitinib for 3 monthes. Then, she underwent nephrectomy and thrombectomy. Histologically, the primary tumor and tumor thro...

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Main Authors: Takuto Hara, Tomoaki Terakawa, Toshiki Hyodo, Naoe Jinbo, Yuzo Nakano, Masato Fujisawa
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Urology Case Reports
Subjects:
Presurgical therapy
Nephrectomy
Renal cell carcinoma
TKI/IO combination Therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2214442021002400
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spelling doaj-5e426e2d1e804473a0551a789bdfea872021-10-07T04:25:35ZengElsevierUrology Case Reports2214-44202021-11-0139101800Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapyTakuto Hara0Tomoaki Terakawa1Toshiki Hyodo2Naoe Jinbo3Yuzo Nakano4Masato Fujisawa5Division of Urology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan; Corresponding author. Department of Urology, Kobe University Graduate School of Medicine, 7Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.Division of Urology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, JapanDivision of Diagnostic Pathology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, JapanDivision of Diagnostic Pathology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, JapanDivision of Urology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, JapanDivision of Urology, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, JapanA 79-year-old female was diagnosed with a right renal tumor with a level II tumor thrombus of the vena cava. presurgical therapy was initiated with a combination of avelumab and axitinib for 3 monthes. Then, she underwent nephrectomy and thrombectomy. Histologically, the primary tumor and tumor thrombus had no viable cells, indicating that pathological complete response was achieved with presurgical tyrosine kinase inhibitor/Immuno-oncology combination therapy. An immunohistological xamination showed very strong staining for tumor-infiltrating lymphocytes in the embolized area of the tumor, with CD8 predominating over CD4.http://www.sciencedirect.com/science/article/pii/S2214442021002400Presurgical therapyNephrectomyRenal cell carcinomaTKI/IO combination Therapy
collection DOAJ
language English
format Article
sources DOAJ
author Takuto Hara
Tomoaki Terakawa
Toshiki Hyodo
Naoe Jinbo
Yuzo Nakano
Masato Fujisawa
spellingShingle Takuto Hara
Tomoaki Terakawa
Toshiki Hyodo
Naoe Jinbo
Yuzo Nakano
Masato Fujisawa
Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapy
Urology Case Reports
Presurgical therapy
Nephrectomy
Renal cell carcinoma
TKI/IO combination Therapy
author_facet Takuto Hara
Tomoaki Terakawa
Toshiki Hyodo
Naoe Jinbo
Yuzo Nakano
Masato Fujisawa
author_sort Takuto Hara
title Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapy
title_short Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapy
title_full Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapy
title_fullStr Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapy
title_full_unstemmed Pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant TKI/IO combination therapy
title_sort pathological complete response of renal cell carcinoma with vena cava tumor thrombus to neoadjuvant tki/io combination therapy
publisher Elsevier
series Urology Case Reports
issn 2214-4420
publishDate 2021-11-01
description A 79-year-old female was diagnosed with a right renal tumor with a level II tumor thrombus of the vena cava. presurgical therapy was initiated with a combination of avelumab and axitinib for 3 monthes. Then, she underwent nephrectomy and thrombectomy. Histologically, the primary tumor and tumor thrombus had no viable cells, indicating that pathological complete response was achieved with presurgical tyrosine kinase inhibitor/Immuno-oncology combination therapy. An immunohistological xamination showed very strong staining for tumor-infiltrating lymphocytes in the embolized area of the tumor, with CD8 predominating over CD4.
topic Presurgical therapy
Nephrectomy
Renal cell carcinoma
TKI/IO combination Therapy
url http://www.sciencedirect.com/science/article/pii/S2214442021002400
work_keys_str_mv AT takutohara pathologicalcompleteresponseofrenalcellcarcinomawithvenacavatumorthrombustoneoadjuvanttkiiocombinationtherapy
AT tomoakiterakawa pathologicalcompleteresponseofrenalcellcarcinomawithvenacavatumorthrombustoneoadjuvanttkiiocombinationtherapy
AT toshikihyodo pathologicalcompleteresponseofrenalcellcarcinomawithvenacavatumorthrombustoneoadjuvanttkiiocombinationtherapy
AT naoejinbo pathologicalcompleteresponseofrenalcellcarcinomawithvenacavatumorthrombustoneoadjuvanttkiiocombinationtherapy
AT yuzonakano pathologicalcompleteresponseofrenalcellcarcinomawithvenacavatumorthrombustoneoadjuvanttkiiocombinationtherapy
AT masatofujisawa pathologicalcompleteresponseofrenalcellcarcinomawithvenacavatumorthrombustoneoadjuvanttkiiocombinationtherapy
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