Isocytosine deaminase Vcz as a novel tool for the prodrug cancer therapy

Isocytosine deaminase Vcz as a novel tool for the prodrug cancer therapy

Abstract Background The cytosine deaminase (CD)/5-fluorocytosine (5-FC) system is among the best explored enzyme/prodrug systems in the field of the suicide gene therapy. Recently, by the screening of the environmental metagenomic libraries we identified a novel isocytosine deaminase (ICD), termed V...

Full description

Bibliographic Details
Main Authors: Arunas Kazlauskas, Adas Darinskas, Rolandas Meškys, Arimantas Tamašauskas, Jaunius Urbonavičius
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Cancer
Subjects:
5-fluoroisocytosine
Isocytosine deaminase
5-fluorouracil
Prodrug-activation system
Cancer therapy
Online Access:http://link.springer.com/article/10.1186/s12885-019-5409-7

Internet

http://link.springer.com/article/10.1186/s12885-019-5409-7

Similar Items