Comparative Genomics Identifies Putative Interspecies Mechanisms Underlying Crbn-Sall4-Linked Thalidomide Embryopathy

Comparative Genomics Identifies Putative Interspecies Mechanisms Underlying Crbn-Sall4-Linked Thalidomide Embryopathy

The identification of thalidomide–Cereblon-induced SALL4 degradation has brought new understanding for thalidomide embryopathy (TE) differences across species. Some questions, however, regarding species variability, still remain. The aim of this study was to detect sequence divergences between speci...

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Bibliographic Details
Main Authors: Thayne Woycinck Kowalski, Gabriela Barreto Caldas-Garcia, Julia do Amaral Gomes, Lucas Rosa Fraga, Lavínia Schuler-Faccini, Mariana Recamonde-Mendoza, Vanessa Rodrigues Paixão-Côrtes, Fernanda Sales Luiz Vianna
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Genetics
Subjects:
IMiDs
teratogenesis
teratogens
comparative genomics
co-expression
C2H2
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2021.680217/full

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