FREQUENCY OF THROMBOCYTOPENIA IN PREGNANCY RELATED HYPERTENSIVE DISORDERS IN PATIENTS PRESENTING AT TERTIARY CARE HOSPITALS OF PESHAWAR

• Main Authors: Rubina nazli, Mohammad Akmal khan, Tasleem akhtar, Nabila Sher Mohammad, Hina aslam, Jamila haider
• Format: Article
• Language: English
• Published: Khyber Medical University 2012-09-01
• Series: Khyber Medical University Journal
• Online Access: https://www.kmuj.kmu.edu.pk/article/view/10471
• ISSN: 2305-2643; 2305-2651

ABSTRACT Objective: To find the frequency of thrombocytopenia in women with pregnancy related hypertensive disorders inpatients presenting at tertiary care hospitals of Peshawar. Methodology: This cross sectional study was conducted from January 2009 to January 2010 in the tertiary referralhealth care facilities of Peshawar. A total of 312 women of gestational age of >20 weeks with pregnancy relatedhypertensive disorders were investigated. They were subdivided into 102 women with gestational hypertension (GroupA), 100 women with pre-eclampsia (Group B), and 110 women with eclampsia (Group C). Ninety healthy pregnantwomen (group D) were chosen as control. All the subjects were selected from the Gynecology and Obstetrics units ofthree tertiary health care facilities of Peshawar. Platelet count was measured by using Hematology Analyzer. The datawas processed on SPSS version 10. Results: The frequency of thrombocytopenia in all patient groups was 21.8% (n=68/312). Individual groups showedthrombocytopenia in 14.6% (Group A), 15% (group B), 34.6% (group C) and 4.5% in controls (group D). Out of 68patients with thrombocytopenia, 38(55.9%) were eclamptic. Overall severe thrombocytopenia was recorded in 27(8.7%)patients, of whom 15(55.6%) were eclamptic. These patients were nine times more likely to have eclampsia as comparedto those having platelet count > 150,000/μL (OR: 9.41; CI: 1.33-188.8; p= 0.008). Conclusion: A high frequency of thrombocytopenia was recorded in the patients with pregnancy related hypertensivedisorders in the tertiary care hospitals of Peshawar. The severity of thrombocytopenia is proportional to the severity ofpregnancy related hypertensive disorders. Key Words: Pregnancy Related Hypertensive Disorders; Platelet Count; Thrombocytopenia; Gestational Hypertension,Pre-Eclampsia.