Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue

Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue

van Haaften et al. show numerical-experimental approach to reconstruct the graft–host response. They interrogate the mechanoregulation in dialysis grafts to solve the disturbed shear stress problem, which can be a cause of neointimal hyperplasia in blood vessels and grafts.

Bibliographic Details
Main Authors: Eline E. van Haaften, Sjeng Quicken, Wouter Huberts, Carlijn V. C. Bouten, Nicholas A. Kurniawan
Format: Article
Language:English
Published: Nature Publishing Group 2021-05-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-02065-6
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spelling doaj-5e25773dc2fe4f8d9d8f013fae7a90002021-05-11T14:54:36ZengNature Publishing GroupCommunications Biology2399-36422021-05-014111210.1038/s42003-021-02065-6Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissueEline E. van Haaften0Sjeng Quicken1Wouter Huberts2Carlijn V. C. Bouten3Nicholas A. Kurniawan4Department of Biomedical Engineering, Eindhoven University of TechnologyDepartment of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht UniversityDepartment of Biomedical Engineering, CARIM School for Cardiovascular Diseases, Maastricht UniversityDepartment of Biomedical Engineering, Eindhoven University of TechnologyDepartment of Biomedical Engineering, Eindhoven University of Technologyvan Haaften et al. show numerical-experimental approach to reconstruct the graft–host response. They interrogate the mechanoregulation in dialysis grafts to solve the disturbed shear stress problem, which can be a cause of neointimal hyperplasia in blood vessels and grafts.https://doi.org/10.1038/s42003-021-02065-6
collection DOAJ
language English
format Article
sources DOAJ
author Eline E. van Haaften
Sjeng Quicken
Wouter Huberts
Carlijn V. C. Bouten
Nicholas A. Kurniawan
spellingShingle Eline E. van Haaften
Sjeng Quicken
Wouter Huberts
Carlijn V. C. Bouten
Nicholas A. Kurniawan
Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue
Communications Biology
author_facet Eline E. van Haaften
Sjeng Quicken
Wouter Huberts
Carlijn V. C. Bouten
Nicholas A. Kurniawan
author_sort Eline E. van Haaften
title Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue
title_short Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue
title_full Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue
title_fullStr Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue
title_full_unstemmed Computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue
title_sort computationally guided in-vitro vascular growth model reveals causal link between flow oscillations and disorganized neotissue
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-05-01
description van Haaften et al. show numerical-experimental approach to reconstruct the graft–host response. They interrogate the mechanoregulation in dialysis grafts to solve the disturbed shear stress problem, which can be a cause of neointimal hyperplasia in blood vessels and grafts.
url https://doi.org/10.1038/s42003-021-02065-6
work_keys_str_mv AT elineevanhaaften computationallyguidedinvitrovasculargrowthmodelrevealscausallinkbetweenflowoscillationsanddisorganizedneotissue
AT sjengquicken computationallyguidedinvitrovasculargrowthmodelrevealscausallinkbetweenflowoscillationsanddisorganizedneotissue
AT wouterhuberts computationallyguidedinvitrovasculargrowthmodelrevealscausallinkbetweenflowoscillationsanddisorganizedneotissue
AT carlijnvcbouten computationallyguidedinvitrovasculargrowthmodelrevealscausallinkbetweenflowoscillationsanddisorganizedneotissue
AT nicholasakurniawan computationallyguidedinvitrovasculargrowthmodelrevealscausallinkbetweenflowoscillationsanddisorganizedneotissue
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