A functional SNP associated with atopic dermatitis controls cell type-specific methylation of the VSTM1 gene locus

A functional SNP associated with atopic dermatitis controls cell type-specific methylation of the VSTM1 gene locus

Abstract Background Expression quantitative trait loci (eQTL) databases represent a valuable resource to link disease-associated SNPs to specific candidate genes whose gene expression is significantly modulated by the SNP under investigation. We previously identified signal inhibitory receptor on le...

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Bibliographic Details
Main Authors: Dilip Kumar, Kia Joo Puan, Anand Kumar Andiappan, Bernett Lee, Geertje H. A. Westerlaken, Doreen Haase, Rossella Melchiotti, Zhuang Li, Nurhashikin Yusof, Josephine Lum, Geraldine Koh, Shihui Foo, Joe Yeong, Alexessander Couto Alves, Juha Pekkanen, Liang Dan Sun, Astrid Irwanto, Benjamin P. Fairfax, Vivek Naranbhai, John E. A. Common, Mark Tang, Chin Keh Chuang, Marjo-Riitta Jarvelin, Julian C. Knight, Xuejun Zhang, Fook Tim Chew, Shyam Prabhakar, Liu Jianjun, De Yun Wang, Francesca Zolezzi, Michael Poidinger, E. Birgitte Lane, Linde Meyaard, Olaf Rötzschke
Format: Article
Language:English
Published: BMC 2017-02-01
Series:Genome Medicine
Subjects:
VSTM1
Signal inhibitory receptor on leukocytes-1 (SIRL-1)
Expression quantitative trait loci (eQTL)
Atopic dermatitis
Monocytes
Reactive oxygen species (ROS)
Online Access:http://link.springer.com/article/10.1186/s13073-017-0404-6

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