Motor Dyscoordination and Alteration of Functional Correlation Between DGKγ and PKCγ in Senescence-Accelerated Mouse Prone 8 (SAMP8)

Motor Dyscoordination and Alteration of Functional Correlation Between DGKγ and PKCγ in Senescence-Accelerated Mouse Prone 8 (SAMP8)

Senescence-accelerated mouse prone 8 (SAMP8) is an animal model of age-related central nervous system (CNS) disorders. Although SAMP8 shows deficits in learning, memory, and emotion, its motor coordination has not been clarified. We have recently reported that DGKγ-regulated PKCγ activity is importa...

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Bibliographic Details
Main Authors: Ryosuke Tsumagari, Kenta Maruo, Takaaki Nakao, Shuji Ueda, Minoru Yamanoue, Yasuhito Shirai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Aging Neuroscience
Subjects:
DGKγ
PKCγ
functional correlation
SAMP8
motor coordination
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.573966/full

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