Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks

Therapeutic resistance in cancer: microRNA regulation of EGFR signaling networks

Receptor tyrosine kinases (RTKs) such as the epidermal growth factor receptor (EGFR) regulate cellular homeostatic processes. EGFR activates downstream signaling cascades that promote tumor cell survival, proliferation and migration. Dysregulation of EGFR signaling as a consequence of overexpression...

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Bibliographic Details
Main Authors: German G. Gomez, Jill Wykosky, Ciro Zanca, Frank B. Furnari, Webster K. Cavenee
Format: Article
Language:English
Published: China Anti-Cancer Association 2013-12-01
Series:Cancer Biology & Medicine
Subjects:
Epidermal growth factor receptor
microRNA
tyrosine kinase inhibitors
therapeutic resistance
Online Access:http://www.cancerbiomed.org/index.php/cocr/article/view/616

Internet

http://www.cancerbiomed.org/index.php/cocr/article/view/616

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