Kidney Disease and Perinatal Programming of Arterial Hypertension: the Results of Experimental Researches

• Main Authors: Olga P. Kovtun, Pavel B. Tsyvian
• Format: Article
• Language: English
• Published: "Paediatrician" Publishers LLC 2018-01-01
• Series: Voprosy Sovremennoj Pediatrii
• Subjects: children; perinatal period; perinatal programming; hypertension; kidneys; oxidative stress
• Online Access: https://vsp.spr-journal.ru/jour/article/view/1834

Deterioration of development conditions in the perinatal period (starvation of the mother, excess sodium ions in her diet, exposure to glucocorticosteroids, placental insufficiency) programs significant  changes in the excretion of sodium ions in the newborn and leads to the development of hypertension. Studies on experimental animals show  that unfavourable conditions of intrauterine development can reduce the effective area of glomerular filtration and its rate. These circumstances  increase the expression of membrane carriers of sodium ions in the  apical membranes, the production of superoxide radicals and enhance  the reabsorption of sodium. The article discusses the potential mechanisms of perinatal programming of renal hypertension in humans.