Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp Conditions

Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp Conditions

Leptin is involved in the endocrine control of energy expenditure and body weight regulation. Previous studies emphasize a relationship between hypoxic states and leptin concentrations. The aim of this study was to investigate the effects of acute hypoxia on leptin concentrations in healthy subjects...

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Main Authors: Andre Schmoller, Michaela Voss, Hartmut Gehring, Sebastian Rudolf, Ulrich Schweiger, Bernd Schultes, Kerstin M. Oltmanns
Format: Article
Language:English
Published: Hindawi Limited 2009-01-01
Series:International Journal of Endocrinology
Online Access:http://dx.doi.org/10.1155/2009/270698
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spelling doaj-5df1cf214e8e4b67b2412138db8098ef2020-11-25T00:00:40ZengHindawi LimitedInternational Journal of Endocrinology1687-83371687-83452009-01-01200910.1155/2009/270698270698Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp ConditionsAndre Schmoller0Michaela Voss1Hartmut Gehring2Sebastian Rudolf3Ulrich Schweiger4Bernd Schultes5Kerstin M. Oltmanns6Department of Psychiatry and Psychotherapy, University of Luebeck, D-23538 Luebeck, GermanyDepartment of Psychiatry and Psychotherapy, University of Luebeck, D-23538 Luebeck, GermanyDepartment of Anaesthesiology, University of Luebeck, D-23538 Luebeck, GermanyDepartment of Psychiatry and Psychotherapy, University of Luebeck, D-23538 Luebeck, GermanyDepartment of Psychiatry and Psychotherapy, University of Luebeck, D-23538 Luebeck, GermanyInterdisciplinary Obesity Center, St. Gallen, CH-9400 Rorschach, SwitzerlandDepartment of Psychiatry and Psychotherapy, University of Luebeck, D-23538 Luebeck, GermanyLeptin is involved in the endocrine control of energy expenditure and body weight regulation. Previous studies emphasize a relationship between hypoxic states and leptin concentrations. The aim of this study was to investigate the effects of acute hypoxia on leptin concentrations in healthy subjects. We examined 14 healthy men. Hypoxic conditions were induced by decreasing oxygen saturation to 75% for 30 minutes. Plasma leptin concentrations were determined at baseline, after 3 hours of euglycemic clamping, during hypoxia, and repeatedly the following 2.5 hours thereafter. Our results show an increase of plasma leptin concentrations in the course of 6 hours of hyperinsulinemic-euglycemic clamping which may reflect diurnal rhythmicity. Notwithstanding, there was no difference between levels of leptin in the hypoxic and the normoxic condition (𝑃=.2). Since we did not find any significant changes in leptin responses upon hypoxia, plasma leptin levels do not seem to be affected by short hypoxic episodes of moderate degree.http://dx.doi.org/10.1155/2009/270698
collection DOAJ
language English
format Article
sources DOAJ
author Andre Schmoller
Michaela Voss
Hartmut Gehring
Sebastian Rudolf
Ulrich Schweiger
Bernd Schultes
Kerstin M. Oltmanns
spellingShingle Andre Schmoller
Michaela Voss
Hartmut Gehring
Sebastian Rudolf
Ulrich Schweiger
Bernd Schultes
Kerstin M. Oltmanns
Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp Conditions
International Journal of Endocrinology
author_facet Andre Schmoller
Michaela Voss
Hartmut Gehring
Sebastian Rudolf
Ulrich Schweiger
Bernd Schultes
Kerstin M. Oltmanns
author_sort Andre Schmoller
title Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp Conditions
title_short Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp Conditions
title_full Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp Conditions
title_fullStr Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp Conditions
title_full_unstemmed Short Hypoxia Does not Affect Plasma Leptin in Healthy Men under Euglycemic Clamp Conditions
title_sort short hypoxia does not affect plasma leptin in healthy men under euglycemic clamp conditions
publisher Hindawi Limited
series International Journal of Endocrinology
issn 1687-8337
1687-8345
publishDate 2009-01-01
description Leptin is involved in the endocrine control of energy expenditure and body weight regulation. Previous studies emphasize a relationship between hypoxic states and leptin concentrations. The aim of this study was to investigate the effects of acute hypoxia on leptin concentrations in healthy subjects. We examined 14 healthy men. Hypoxic conditions were induced by decreasing oxygen saturation to 75% for 30 minutes. Plasma leptin concentrations were determined at baseline, after 3 hours of euglycemic clamping, during hypoxia, and repeatedly the following 2.5 hours thereafter. Our results show an increase of plasma leptin concentrations in the course of 6 hours of hyperinsulinemic-euglycemic clamping which may reflect diurnal rhythmicity. Notwithstanding, there was no difference between levels of leptin in the hypoxic and the normoxic condition (𝑃=.2). Since we did not find any significant changes in leptin responses upon hypoxia, plasma leptin levels do not seem to be affected by short hypoxic episodes of moderate degree.
url http://dx.doi.org/10.1155/2009/270698
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