Differential impact of hepatic deficiency and total body inhibition of MTP on cholesterol metabolism and RCT in mice[S]

Differential impact of hepatic deficiency and total body inhibition of MTP on cholesterol metabolism and RCT in mice[S]

Because apoB-containing lipoproteins are pro-atherogenic and their secretion by liver and intestine largely depends on microsomal triglyceride transfer protein (MTP) activity, MTP inhibition strategies are actively pursued. How decreasing the secretion of apoB-containing lipoproteins affects intrace...

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Bibliographic Details
Main Authors: Arne Dikkers, Wijtske Annema, Jan Freark de Boer, Jahangir Iqbal, M. Mahmood Hussain, UweJ.F. Tietge
Format: Article
Language:English
Published: Elsevier 2014-05-01
Series:Journal of Lipid Research
Subjects:
bile
high density lipoprotein
lipoprotein metabolism
liver metabolism
very low density lipoprotein
transintestinal cholesterol excretion
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520375015

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http://www.sciencedirect.com/science/article/pii/S0022227520375015

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