| Summary: | <p>Abstract</p> <p>Background</p> <p>The design and applications of antimicrobial polymers is a growing field. Antimicrobial polymers can help to solve the problems associated with the use of conventional antimicrobial agents. Polymers with active functional groups can act as a carrier system for antimicrobial agents. In our study, we aim to prepare and develop some antimicrobial polymers for biomedical applications and water treatment.</p> <p>Results</p> <p>The antimicrobial polymers based on polyacrylonitrile (PAN) were prepared. Functional groups were created onto polyacrylonitrile via amination using different types of diamines such as ethylenediamine (EDA) and hexamethylenediamine (HMDA) to yield amine-terminated polymers. Antimicrobial polymers were obtained by immobilization of benzaldehyde and its derivatives which include, 4-hydroxybenzaldehyde and 2,4-dihydroxybenzaldehyde onto amine-terminated polymers. The antimicrobial activity of the prepared polymers against different types of microorganisms including Gram-positive bacteria (<it>Staphylococcus aureus),</it> Gram-negative bacteria (<it>Pseudomonas aeruginosa</it>; <it>Escherichia coli</it>; and <it>Salmonella typhi</it>) as well as fungi (<it>Aspergillus flavus</it>, <it>Aspergillus niger</it>, <it>Candida albicans</it>, <it>Cryptpcoccus neoformans</it>) were explored by the cut plug method and viable cell counting methods.</p> <p>Conclusions</p> <p>Amine-terminated polyacrylonitrile were used as a novel polymeric carrier for benzaldehyde derivatives as antimicrobial agents. The prepared polymers can inhibit the growth of the microorganisms. The activity was varied according to the tested microorganism as well as the polymer microstructure. It was found that the activity increased with increasing the number phenolic hydroxyl group of the bioactive group. Finally, it is anticipated that the prepared antimicrobial polymers would be of great help in the field of biomedical applications and biological water treatment.</p>
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