Cancer Detection from Plasma Cell-Free DNA

Cancer Detection from Plasma Cell-Free DNA

Liquid biopsy of cell-free DNA (cfDNA) has attracted much attention for its promise to realize pan-cancer detection in a non-invasive way. The whole-genome bisulfite sequencing (WGBS) is widely used in cfDNA sequencing analysis and lays the foundation for further study on cfDNA. The cfDNA released b...

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Main Author: Chen Li
Format: Article
Language:English
Published: EDP Sciences 2020-01-01
Series:E3S Web of Conferences
Online Access:https://www.e3s-conferences.org/articles/e3sconf/pdf/2020/78/e3sconf_iseese2020_03049.pdf
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spelling doaj-5de8eafff185476789e8f162de5ce0502021-04-02T16:33:17ZengEDP SciencesE3S Web of Conferences2267-12422020-01-012180304910.1051/e3sconf/202021803049e3sconf_iseese2020_03049Cancer Detection from Plasma Cell-Free DNAChen Li0Department of Biomedical Engineering, Engineering College, Peking UniversityLiquid biopsy of cell-free DNA (cfDNA) has attracted much attention for its promise to realize pan-cancer detection in a non-invasive way. The whole-genome bisulfite sequencing (WGBS) is widely used in cfDNA sequencing analysis and lays the foundation for further study on cfDNA. The cfDNA released by multiple tissues carries genetic and epigenetic information. Methylation patterns, copy number variation (CNV) and fragmentation changes have been discovered in previous studies and achieved a promising accuracy. In this review, different cancer detection methods based on these three biomarkers are introduced. In addition, feature fusion is discussed for its potential in enhancing performance in clinical applications.https://www.e3s-conferences.org/articles/e3sconf/pdf/2020/78/e3sconf_iseese2020_03049.pdf
collection DOAJ
language English
format Article
sources DOAJ
author Chen Li
spellingShingle Chen Li
Cancer Detection from Plasma Cell-Free DNA
E3S Web of Conferences
author_facet Chen Li
author_sort Chen Li
title Cancer Detection from Plasma Cell-Free DNA
title_short Cancer Detection from Plasma Cell-Free DNA
title_full Cancer Detection from Plasma Cell-Free DNA
title_fullStr Cancer Detection from Plasma Cell-Free DNA
title_full_unstemmed Cancer Detection from Plasma Cell-Free DNA
title_sort cancer detection from plasma cell-free dna
publisher EDP Sciences
series E3S Web of Conferences
issn 2267-1242
publishDate 2020-01-01
description Liquid biopsy of cell-free DNA (cfDNA) has attracted much attention for its promise to realize pan-cancer detection in a non-invasive way. The whole-genome bisulfite sequencing (WGBS) is widely used in cfDNA sequencing analysis and lays the foundation for further study on cfDNA. The cfDNA released by multiple tissues carries genetic and epigenetic information. Methylation patterns, copy number variation (CNV) and fragmentation changes have been discovered in previous studies and achieved a promising accuracy. In this review, different cancer detection methods based on these three biomarkers are introduced. In addition, feature fusion is discussed for its potential in enhancing performance in clinical applications.
url https://www.e3s-conferences.org/articles/e3sconf/pdf/2020/78/e3sconf_iseese2020_03049.pdf
work_keys_str_mv AT chenli cancerdetectionfromplasmacellfreedna
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