Cigarette Smoke Extract Stimulates Rat Pulmonary Artery Smooth Muscle Cell Proliferation via PKC-PDGFB Signaling

Cigarette Smoke Extract Stimulates Rat Pulmonary Artery Smooth Muscle Cell Proliferation via PKC-PDGFB Signaling

Accumulating evidence suggests a direct role for cigarette smoke in pulmonary vascular remodeling, which contributes to the development of pulmonary hypertension. However, the molecular mechanisms underlying this process remain poorly understood. Platelet-derived growth factor (PDGF) is a potential...

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Bibliographic Details
Main Authors:	Ai-ping Xing, Yong-cheng Du, Xiao-yun Hu, Jian-ying Xu, Huan-ping Zhang, Yi Li, Xin Nie
Format:	Article
Language:	English
Published:	Hindawi Limited 2012-01-01
Series:	Journal of Biomedicine and Biotechnology
Online Access:	http://dx.doi.org/10.1155/2012/534384

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