Predicting the Cytotoxic Potency of Cigarette Smoke by Assessing the Thioredoxin Reductase Inhibitory Capacity of Cigarette Smoke Extract

Predicting the Cytotoxic Potency of Cigarette Smoke by Assessing the Thioredoxin Reductase Inhibitory Capacity of Cigarette Smoke Extract

The present study investigated the influence of the cigarette smoke extract (CSE) on mammalian thioredoxin reductase (TrxR) activity. TrxR is a selenoenzyme with a selenocysteine (Sec) residue exposed on the enzyme’s surface. This unique Sec residue is particularly susceptible to modification by num...

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Bibliographic Details
Main Authors: Longjie Zhang, Min Ning, Yingbo Xu, Chenghui Wang, Guangshan Zhao, Qingqing Cao, Jinsong Zhang
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:International Journal of Environmental Research and Public Health
Subjects:
cigarette smoke
thioredoxin reductase
cytotoxicity
high throughput
Online Access:http://www.mdpi.com/1660-4601/13/3/348

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