Designing novel quercetin derivatives as matrix metalloproteinase-9 inhibitors in colon carcinoma: An In vitro and in silico approach

Designing novel quercetin derivatives as matrix metalloproteinase-9 inhibitors in colon carcinoma: An In vitro and in silico approach

Background: Matrix metalloproteinase-9 (MMP-9) plays an important role in activating several signaling molecules and pathways during inflammation, wound healing, and cancer progression. Since flavonoids have been shown to exhibit anti-inflammatory properties, we assessed the antiproliferative activi...

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Bibliographic Details
Main Authors: Sangeeta Ballav, Kiran Bharat Lokhande, Ipshita Dabhi, Sonal Inje, Amit Ranjan, K Venkateswara Swamy, Soumya Basu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2020-01-01
Series:Journal of Dental Research and Review
Subjects:
colon cancer
matrix metalloproteinase-9
molecular docking
molecular dynamic simulation
quercetin
Online Access:http://www.jdrr.org/article.asp?issn=2348-2915;year=2020;volume=7;issue=5;spage=30;epage=35;aulast=Ballav

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