Effect of lipid lowering mixture on blood lipid metabolism, LDL oxidation susceptibility and blood viscosity and coagulation in experimental hyperlipidemia rats

• Main Authors: Xue-Bing Luan, Liang Ma
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2019-02-01
• Series: Journal of Hainan Medical University
• Online Access: http://www.hnykdxxb.com/PDF/201904/04.pdf

Objective: To investigate the effect of lipid lowering mixture on blood lipid metabolism, LDL oxidative susceptibility and blood viscosity and coagulation in experimental hyperlipidemia rats. Method: Select 60 male Wistar rats were randomly divided into six groups, ten rats in each group were recorded as low as lipid-lowering mixture, high dose group and simvastatin group, model group and control group. Patients in control group were treated with basic feed for feeding, other groups of rats are used high fat diet were fed to establish hyperlipidemia rat model, in the process of modeling and prophylactically, determination of rats after 10 weeks of lipid metabolism and susceptibility of LDL to oxidation and blood viscosity concentration coagulation state. Result: Antioxidant capacity of the model group rat’s serum LDL-C decreased significantly, and simvastatin group and three groups of lipid-lowering mixture group rats serum LDL antioxidant capacity were significantly enhanced; and high lipid mixture, LDL antioxidant ability in middle dose group rats were significantly higher than those of the Jiangzhi Decoction low dose group rats (P<0.05). Lipid mixture of high, middle dose group rats of EET and ETA P, ETA B (high, medium and low shear), IED, HCT, the role of the IEA was significantly higher in Jiangzhi Decoction low dose group rats (P<0.05 or P<0.05). Conclusion: Lipid-lowering mixture on experimental hyperlipidemia rats blood lipid metabolism and blood viscosity concentration coagulation state has a good regulatory role, and lipid-lowering mixture on blood lipid and blood flow abnormalities lipid-lowering mixture can also play a good regulation and therapeutic effect.