Hospitalization rates and outcome of invasive bacterial vaccine-preventable diseases in Tuscany: a historical cohort study of the 2000–2016 period

Abstract Background Invasive bacterial diseases (IBD) are a serious cause of hospitalization, sequelae and mortality. Albeit a low incidence, an increase in cases due to H. influenzae was registered in the past 4 years and, in the Tuscany region, an excess of cases due to N. meningitidis since 2015...

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Main Authors: Elena Chiappini, Federica Inturrisi, Elisa Orlandini, Maurizio de Martino, Chiara de Waure
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Infectious Diseases
Subjects:
Online Access:http://link.springer.com/article/10.1186/s12879-018-3316-1
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spelling doaj-5db65673bac74e3ba226c814ee19ae352020-11-25T03:36:11ZengBMCBMC Infectious Diseases1471-23342018-08-0118111110.1186/s12879-018-3316-1Hospitalization rates and outcome of invasive bacterial vaccine-preventable diseases in Tuscany: a historical cohort study of the 2000–2016 periodElena Chiappini0Federica Inturrisi1Elisa Orlandini2Maurizio de Martino3Chiara de Waure4Anna Meyer Children’s University Hospital, Department of Health Sciences, University of FlorenceDepartment of Epidemiology & Biostatistics, VU University Medical Center (VUmc)Tuscany Regional Government Department of Right to Health and Solidarity Policies, Information Technology SectionAnna Meyer Children’s University Hospital, Department of Health Sciences, University of FlorenceDepartment of Experimental Medicine, University of PerugiaAbstract Background Invasive bacterial diseases (IBD) are a serious cause of hospitalization, sequelae and mortality. Albeit a low incidence, an increase in cases due to H. influenzae was registered in the past 4 years and, in the Tuscany region, an excess of cases due to N. meningitidis since 2015 is alarming. The purpose of this study is to deepen the knowledge of IBD epidemiology in Tuscany with particular attention to temporal trends. Methods Tuscan residents hospitalized for IBD from January 1st 2000 to March 18th 2016 were selected from the regional hospital discharge database based on ICD-9-CM codes. Age-specific and standardized hospitalization rates were calculated together with case-fatality rates (CFRs). A time-trend analysis was performed; whereas, prognostic factors of death were investigated through univariable and multivariable analyses. Results The average standardized hospitalization rates for invasive meningococcal diseases (IMD), invasive pneumococcal diseases and invasive diseases due to H. influenzae from 2000 to 2016 were 0.6, 1.8, and 0.2 per 100,000, respectively. The average CFRs were 10.5%, 14.5% and 11.5% respectively with higher values in the elderly. Older age was significantly associated with higher risk of death from all IBD. A significant reduction in hospitalization rates for IMD was observed after meningococcal C conjugate vaccine introduction. The Annual Percentage Change (APC) was -13.5 (95% confidence interval (CI) -22.3; -3.5) in 2005–2013 but has risen since that period. Furthermore, a significant increasing trend of invasive diseases due to H. influenzae was observed from 2005 onwards in children 1–4 years old (APC 13.3; 95% CI 0; 28.3). Conclusions This study confirms changes in the epidemiology of invasive diseases due to H. influenzae and IMD. Furthermore, attention is called to the prevention of IBD in the elderly because of the age group’s significantly higher rate of hospitalizations and deaths for all types of IBD.http://link.springer.com/article/10.1186/s12879-018-3316-1Invasive bacterial diseasesHospitalization, trend
collection DOAJ
language English
format Article
sources DOAJ
author Elena Chiappini
Federica Inturrisi
Elisa Orlandini
Maurizio de Martino
Chiara de Waure
spellingShingle Elena Chiappini
Federica Inturrisi
Elisa Orlandini
Maurizio de Martino
Chiara de Waure
Hospitalization rates and outcome of invasive bacterial vaccine-preventable diseases in Tuscany: a historical cohort study of the 2000–2016 period
BMC Infectious Diseases
Invasive bacterial diseases
Hospitalization, trend
author_facet Elena Chiappini
Federica Inturrisi
Elisa Orlandini
Maurizio de Martino
Chiara de Waure
author_sort Elena Chiappini
title Hospitalization rates and outcome of invasive bacterial vaccine-preventable diseases in Tuscany: a historical cohort study of the 2000–2016 period
title_short Hospitalization rates and outcome of invasive bacterial vaccine-preventable diseases in Tuscany: a historical cohort study of the 2000–2016 period
title_full Hospitalization rates and outcome of invasive bacterial vaccine-preventable diseases in Tuscany: a historical cohort study of the 2000–2016 period
title_fullStr Hospitalization rates and outcome of invasive bacterial vaccine-preventable diseases in Tuscany: a historical cohort study of the 2000–2016 period
title_full_unstemmed Hospitalization rates and outcome of invasive bacterial vaccine-preventable diseases in Tuscany: a historical cohort study of the 2000–2016 period
title_sort hospitalization rates and outcome of invasive bacterial vaccine-preventable diseases in tuscany: a historical cohort study of the 2000–2016 period
publisher BMC
series BMC Infectious Diseases
issn 1471-2334
publishDate 2018-08-01
description Abstract Background Invasive bacterial diseases (IBD) are a serious cause of hospitalization, sequelae and mortality. Albeit a low incidence, an increase in cases due to H. influenzae was registered in the past 4 years and, in the Tuscany region, an excess of cases due to N. meningitidis since 2015 is alarming. The purpose of this study is to deepen the knowledge of IBD epidemiology in Tuscany with particular attention to temporal trends. Methods Tuscan residents hospitalized for IBD from January 1st 2000 to March 18th 2016 were selected from the regional hospital discharge database based on ICD-9-CM codes. Age-specific and standardized hospitalization rates were calculated together with case-fatality rates (CFRs). A time-trend analysis was performed; whereas, prognostic factors of death were investigated through univariable and multivariable analyses. Results The average standardized hospitalization rates for invasive meningococcal diseases (IMD), invasive pneumococcal diseases and invasive diseases due to H. influenzae from 2000 to 2016 were 0.6, 1.8, and 0.2 per 100,000, respectively. The average CFRs were 10.5%, 14.5% and 11.5% respectively with higher values in the elderly. Older age was significantly associated with higher risk of death from all IBD. A significant reduction in hospitalization rates for IMD was observed after meningococcal C conjugate vaccine introduction. The Annual Percentage Change (APC) was -13.5 (95% confidence interval (CI) -22.3; -3.5) in 2005–2013 but has risen since that period. Furthermore, a significant increasing trend of invasive diseases due to H. influenzae was observed from 2005 onwards in children 1–4 years old (APC 13.3; 95% CI 0; 28.3). Conclusions This study confirms changes in the epidemiology of invasive diseases due to H. influenzae and IMD. Furthermore, attention is called to the prevention of IBD in the elderly because of the age group’s significantly higher rate of hospitalizations and deaths for all types of IBD.
topic Invasive bacterial diseases
Hospitalization, trend
url http://link.springer.com/article/10.1186/s12879-018-3316-1
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