Targeting CD44 by CRISPR-Cas9 in Multi-Drug Resistant Osteosarcoma Cells

Targeting CD44 by CRISPR-Cas9 in Multi-Drug Resistant Osteosarcoma Cells

Background/Aims: Drug resistance is the main difficulty for the current treatment for osteosarcoma. Cluster of differentiation 44 (CD44) is a receptor for hyaluronic acid (HA) and HA-binding has been proven to participate in various biological tumor activities, including tumor progression, metastasi...

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Bibliographic Details
Main Authors: Zheng Xiao, Jia Wan, Ayub Abdulle Nur, Pencheng Dou, Henry Mankin, Tang Liu, Zhengxiao Ouyang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Osteosarcoma
CRISPR-Cas9
CD44
Drug resistance
Gene therapy
Online Access:https://www.karger.com/Article/FullText/495714

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