RhoC: a fascinating journey from a cytoskeletal organizer to a Cancer stem cell therapeutic target

RhoC: a fascinating journey from a cytoskeletal organizer to a Cancer stem cell therapeutic target

Abstract Tumor heterogeneity results in differential response to therapy due to the existence of plastic tumor cells, called cancer stem cells (CSCs), which exhibit the property of resistance to therapy, invasion and metastasis. These cells have a distinct, signaling network active at every stage of...

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Bibliographic Details
Main Authors: Pavana Thomas, Annapurna Pranatharthi, Cecil Ross, Sweta Srivastava
Format: Article
Language:English
Published: BMC 2019-07-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
RhoC
Cancer stem cells
Tumor phenotypes
Therapy resistance
Online Access:http://link.springer.com/article/10.1186/s13046-019-1327-4

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