Early Secreted Antigen ESAT-6 of Mycobacterium Tuberculosis Promotes Apoptosis of Macrophages via Targeting the MicroRNA155-SOCS1 Interaction

Early Secreted Antigen ESAT-6 of Mycobacterium Tuberculosis Promotes Apoptosis of Macrophages via Targeting the MicroRNA155-SOCS1 Interaction

Background: The early secreted antigenic target 6-kDa protein (ESAT-6) of Mycobacterium tuberculosis (Mtb) not only acts as a key player for virulence but also exhibits a strong immunotherapeutic potential against Mtb. However, little is known about the molecular basis for its potential in immunothe...

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Bibliographic Details
Main Authors: Shaojun Yang, Fake Li, Shuangrong Jia, Kejun Zhang, Wenbing Jiang, Ya Shang, Kai Chang, Shaoli Deng, Ming Chen
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2015-02-01
Series:Cellular Physiology and Biochemistry
Subjects:
ESAT-6
microRNA-155
SOCS1
TLR2
Apoptosis
Online Access:http://www.karger.com/Article/FullText/373950

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