Long-Term Survival in a Case of Pleomorphic Carcinoma with a Brain Metastasis

Long-Term Survival in a Case of Pleomorphic Carcinoma with a Brain Metastasis

Pleomorphic carcinoma (PC) is a rare malignant lung tumor with a poorer prognosis compared to other histological types of non-small cell lung cancer. However, several recent immunohistochemical studies revealed that a low MIB-1 index is a good prognostic marker in patients with PC. We report the cas...

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Main Authors: Keiji Yamanashi, Satoshi Marumo, Koki Miura, Masahiro Kawashima
Format: Article
Language:English
Published: Karger Publishers 2014-12-01
Series:Case Reports in Oncology
Subjects:
Lung cancer surgery
Adjuvant/neoadjuvant therapy
Metastases
Online Access:http://www.karger.com/Article/FullText/368186
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spelling doaj-5d97fe1ab2af4927b1c4a28c88904f892020-11-24T23:39:15ZengKarger PublishersCase Reports in Oncology1662-65752014-12-017379980310.1159/000368186368186Long-Term Survival in a Case of Pleomorphic Carcinoma with a Brain MetastasisKeiji YamanashiSatoshi MarumoKoki MiuraMasahiro KawashimaPleomorphic carcinoma (PC) is a rare malignant lung tumor with a poorer prognosis compared to other histological types of non-small cell lung cancer. However, several recent immunohistochemical studies revealed that a low MIB-1 index is a good prognostic marker in patients with PC. We report the case of a patient with PC and a single brain metastasis that achieved long-term recurrence-free survival following treatment with combined modality therapy. In this case, the MIB-1 index was reduced by gemcitabine-based chemotherapy, which may have led to long-term disease-free survival. The MIB-1 index may be a useful biomarker for the response to chemotherapy.http://www.karger.com/Article/FullText/368186Lung cancer surgeryAdjuvant/neoadjuvant therapyMetastases
collection DOAJ
language English
format Article
sources DOAJ
author Keiji Yamanashi
Satoshi Marumo
Koki Miura
Masahiro Kawashima
spellingShingle Keiji Yamanashi
Satoshi Marumo
Koki Miura
Masahiro Kawashima
Long-Term Survival in a Case of Pleomorphic Carcinoma with a Brain Metastasis
Case Reports in Oncology
Lung cancer surgery
Adjuvant/neoadjuvant therapy
Metastases
author_facet Keiji Yamanashi
Satoshi Marumo
Koki Miura
Masahiro Kawashima
author_sort Keiji Yamanashi
title Long-Term Survival in a Case of Pleomorphic Carcinoma with a Brain Metastasis
title_short Long-Term Survival in a Case of Pleomorphic Carcinoma with a Brain Metastasis
title_full Long-Term Survival in a Case of Pleomorphic Carcinoma with a Brain Metastasis
title_fullStr Long-Term Survival in a Case of Pleomorphic Carcinoma with a Brain Metastasis
title_full_unstemmed Long-Term Survival in a Case of Pleomorphic Carcinoma with a Brain Metastasis
title_sort long-term survival in a case of pleomorphic carcinoma with a brain metastasis
publisher Karger Publishers
series Case Reports in Oncology
issn 1662-6575
publishDate 2014-12-01
description Pleomorphic carcinoma (PC) is a rare malignant lung tumor with a poorer prognosis compared to other histological types of non-small cell lung cancer. However, several recent immunohistochemical studies revealed that a low MIB-1 index is a good prognostic marker in patients with PC. We report the case of a patient with PC and a single brain metastasis that achieved long-term recurrence-free survival following treatment with combined modality therapy. In this case, the MIB-1 index was reduced by gemcitabine-based chemotherapy, which may have led to long-term disease-free survival. The MIB-1 index may be a useful biomarker for the response to chemotherapy.
topic Lung cancer surgery
Adjuvant/neoadjuvant therapy
Metastases
url http://www.karger.com/Article/FullText/368186
work_keys_str_mv AT keijiyamanashi longtermsurvivalinacaseofpleomorphiccarcinomawithabrainmetastasis
AT satoshimarumo longtermsurvivalinacaseofpleomorphiccarcinomawithabrainmetastasis
AT kokimiura longtermsurvivalinacaseofpleomorphiccarcinomawithabrainmetastasis
AT masahirokawashima longtermsurvivalinacaseofpleomorphiccarcinomawithabrainmetastasis
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