Semicarbazone EGA Inhibits Uptake of Diphtheria Toxin into Human Cells and Protects Cells from Intoxication

Semicarbazone EGA Inhibits Uptake of Diphtheria Toxin into Human Cells and Protects Cells from Intoxication

Diphtheria toxin is a single-chain protein toxin that invades human cells by receptor-mediated endocytosis. In acidic endosomes, its translocation domain inserts into endosomal membranes and facilitates the transport of the catalytic domain (DTA) from endosomal lumen into the host cell cytosol. Here...

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Bibliographic Details
Main Authors: Leonie Schnell, Ann-Katrin Mittler, Andrea Mattarei, Domenico Azarnia Tehran, Cesare Montecucco, Holger Barth
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Toxins
Subjects:
diphtheria
diphtheria toxin
cellular uptake
membrane transport
EGA
Online Access:http://www.mdpi.com/2072-6651/8/7/221

Internet

http://www.mdpi.com/2072-6651/8/7/221

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