Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants

Maintaining protein integrity at the inner nuclear membrane (INM) is critical for eukaryotic cellular function. Here, using proximity-labeling proteomics, Huang et al. profile the INM in Arabidopsis and identify the CDC48 complex and PUX proteins as components of an INM protein degradation pathway.

Bibliographic Details
Main Authors: Aobo Huang, Yu Tang, Xuetao Shi, Min Jia, Jinheng Zhu, Xiaohan Yan, Huiqin Chen, Yangnan Gu
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16744-1
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spelling doaj-5d94d797b1214b84be331faa37e17ca32021-07-04T11:47:50ZengNature Publishing GroupNature Communications2041-17232020-06-0111111010.1038/s41467-020-16744-1Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plantsAobo Huang0Yu Tang1Xuetao Shi2Min Jia3Jinheng Zhu4Xiaohan Yan5Huiqin Chen6Yangnan Gu7Tsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua UniversityDepartment of Plant and Microbial Biology, University of CaliforniaTsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua UniversityDepartment of Plant and Microbial Biology, University of CaliforniaTsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua UniversityTsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua UniversityTsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua UniversityDepartment of Plant and Microbial Biology, University of CaliforniaMaintaining protein integrity at the inner nuclear membrane (INM) is critical for eukaryotic cellular function. Here, using proximity-labeling proteomics, Huang et al. profile the INM in Arabidopsis and identify the CDC48 complex and PUX proteins as components of an INM protein degradation pathway.https://doi.org/10.1038/s41467-020-16744-1
collection DOAJ
language English
format Article
sources DOAJ
author Aobo Huang
Yu Tang
Xuetao Shi
Min Jia
Jinheng Zhu
Xiaohan Yan
Huiqin Chen
Yangnan Gu
spellingShingle Aobo Huang
Yu Tang
Xuetao Shi
Min Jia
Jinheng Zhu
Xiaohan Yan
Huiqin Chen
Yangnan Gu
Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants
Nature Communications
author_facet Aobo Huang
Yu Tang
Xuetao Shi
Min Jia
Jinheng Zhu
Xiaohan Yan
Huiqin Chen
Yangnan Gu
author_sort Aobo Huang
title Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants
title_short Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants
title_full Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants
title_fullStr Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants
title_full_unstemmed Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants
title_sort proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-06-01
description Maintaining protein integrity at the inner nuclear membrane (INM) is critical for eukaryotic cellular function. Here, using proximity-labeling proteomics, Huang et al. profile the INM in Arabidopsis and identify the CDC48 complex and PUX proteins as components of an INM protein degradation pathway.
url https://doi.org/10.1038/s41467-020-16744-1
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