Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants
Maintaining protein integrity at the inner nuclear membrane (INM) is critical for eukaryotic cellular function. Here, using proximity-labeling proteomics, Huang et al. profile the INM in Arabidopsis and identify the CDC48 complex and PUX proteins as components of an INM protein degradation pathway.
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2020-06-01
|
Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-020-16744-1 |
id |
doaj-5d94d797b1214b84be331faa37e17ca3 |
---|---|
record_format |
Article |
spelling |
doaj-5d94d797b1214b84be331faa37e17ca32021-07-04T11:47:50ZengNature Publishing GroupNature Communications2041-17232020-06-0111111010.1038/s41467-020-16744-1Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plantsAobo Huang0Yu Tang1Xuetao Shi2Min Jia3Jinheng Zhu4Xiaohan Yan5Huiqin Chen6Yangnan Gu7Tsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua UniversityDepartment of Plant and Microbial Biology, University of CaliforniaTsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua UniversityDepartment of Plant and Microbial Biology, University of CaliforniaTsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua UniversityTsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua UniversityTsinghua-Peking Joint Center for Life Sciences, Center for Plant Biology, School of Life Sciences, Tsinghua UniversityDepartment of Plant and Microbial Biology, University of CaliforniaMaintaining protein integrity at the inner nuclear membrane (INM) is critical for eukaryotic cellular function. Here, using proximity-labeling proteomics, Huang et al. profile the INM in Arabidopsis and identify the CDC48 complex and PUX proteins as components of an INM protein degradation pathway.https://doi.org/10.1038/s41467-020-16744-1 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Aobo Huang Yu Tang Xuetao Shi Min Jia Jinheng Zhu Xiaohan Yan Huiqin Chen Yangnan Gu |
spellingShingle |
Aobo Huang Yu Tang Xuetao Shi Min Jia Jinheng Zhu Xiaohan Yan Huiqin Chen Yangnan Gu Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants Nature Communications |
author_facet |
Aobo Huang Yu Tang Xuetao Shi Min Jia Jinheng Zhu Xiaohan Yan Huiqin Chen Yangnan Gu |
author_sort |
Aobo Huang |
title |
Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants |
title_short |
Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants |
title_full |
Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants |
title_fullStr |
Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants |
title_full_unstemmed |
Proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants |
title_sort |
proximity labeling proteomics reveals critical regulators for inner nuclear membrane protein degradation in plants |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2020-06-01 |
description |
Maintaining protein integrity at the inner nuclear membrane (INM) is critical for eukaryotic cellular function. Here, using proximity-labeling proteomics, Huang et al. profile the INM in Arabidopsis and identify the CDC48 complex and PUX proteins as components of an INM protein degradation pathway. |
url |
https://doi.org/10.1038/s41467-020-16744-1 |
work_keys_str_mv |
AT aobohuang proximitylabelingproteomicsrevealscriticalregulatorsforinnernuclearmembraneproteindegradationinplants AT yutang proximitylabelingproteomicsrevealscriticalregulatorsforinnernuclearmembraneproteindegradationinplants AT xuetaoshi proximitylabelingproteomicsrevealscriticalregulatorsforinnernuclearmembraneproteindegradationinplants AT minjia proximitylabelingproteomicsrevealscriticalregulatorsforinnernuclearmembraneproteindegradationinplants AT jinhengzhu proximitylabelingproteomicsrevealscriticalregulatorsforinnernuclearmembraneproteindegradationinplants AT xiaohanyan proximitylabelingproteomicsrevealscriticalregulatorsforinnernuclearmembraneproteindegradationinplants AT huiqinchen proximitylabelingproteomicsrevealscriticalregulatorsforinnernuclearmembraneproteindegradationinplants AT yangnangu proximitylabelingproteomicsrevealscriticalregulatorsforinnernuclearmembraneproteindegradationinplants |
_version_ |
1721319835856535552 |