Sex- and age‐dependent alterations of splenic immune cell profile and NK cell phenotypes and function in C57BL/6J mice

Sex- and age‐dependent alterations of splenic immune cell profile and NK cell phenotypes and function in C57BL/6J mice

Abstract Background Physiological homeostasis decline, immunosenescence, and increased risk for multiple diseases, including neurodegeneration, are all hallmarks of ageing. Importantly, it is known that the ageing process is sex-biased. For example, there are sex differences in predisposition for mu...

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Bibliographic Details
Main Authors: Kelly B. Menees, Rachael H. Earls, Jaegwon Chung, Janna Jernigan, Nikolay M. Filipov, Jessica M. Carpenter, Jae-Kyung Lee
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Immunity & Ageing
Subjects:
Ageing
Sex
Natural killer cell
Immunosenescence
α-synuclein
Online Access:https://doi.org/10.1186/s12979-021-00214-3

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