Proliferation, angiogenesis and differentiation related markers in compact and follicular-compact thyroid carcinomas in dogs

• Main Authors: P. Pessina, V.A. Castillo, D. César, I. Sartore, A. Meikle
• Format: Article
• Language: English
• Published: Tripoli University 2016-12-01
• Series: Open Veterinary Journal
• Subjects: Canine; Histology; Immunohistochemistry; Thyroid carcinoma
• Online Access: http://www.openveterinaryjournal.com/2016/Volume%206%20(3)/OVJ-141-06-16%20P.%20Pessina%20et%20al.pdf

Immunohistochemical markers (IGF-1, IGF-1R, VEGF, FGF-2, RARα and RXR) were evaluated in healthy canine thyroid glands (n=8) and in follicular-compact (n=8) and compact thyroid carcinomas (n=8). IGF-1, IGF-1R and VEGF expression was higher in fibroblasts and endothelial cells of compact carcinoma than in healthy glands (P < 0.05). Compared to follicular-compact carcinoma, compact carcinoma had higher IGF-1R expression in fibroblasts, and higher FGF-2 expression in endothelial cells (P < 0.05). RARα expression was higher in endothelial cells of compact carcinoma than in those of other groups (P < 0.05). The upregulation of these proliferation- and angiogenesis-related factors in endothelial cells and/or fibroblasts and not in follicular cells of compact carcinoma compared to healthy glands supports the relevance of stromal cells in cancer progression.