Determinação rápida de hidroquinona usando análise por injeção em batelada (BIA) com detecção amperométrica

A fast analytical method for determination of hydroquinone in pharmaceutical formulations employing batch injection analysis (BIA) with amperometric detection using a boron-doped diamond electrode is described. The supporting electrolyte was a 0.1 mol L-1 H2SO4 solution (the single reagent used for...

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Bibliographic Details
Main Authors: Rafael Rodrigues Cunha, Thiago Faria Tormin, Eduardo Mathias Richter, Rodrigo Alejandro Abarza Munoz
Format: Article
Language:English
Published: Sociedade Brasileira de Química 2013-01-01
Series:Química Nova
Subjects:
BIA
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422013000500009&lng=en&tlng=en
Description
Summary:A fast analytical method for determination of hydroquinone in pharmaceutical formulations employing batch injection analysis (BIA) with amperometric detection using a boron-doped diamond electrode is described. The supporting electrolyte was a 0.1 mol L-1 H2SO4 solution (the single reagent used for analysis). The method showed good repeatability (RSD of 0.45%, n=20), wide linear range (from 10 to 2000 µmol L-1, R=0.9999), low detection limit (0.016 µmol L-1) and satisfactory recovery values (91-96%). Accuracy of the method was evaluated by comparative analyses using high-performance liquid-chromatography. The ability to replace the electronic pipette by disposable syringes (injection procedure) in BIA systems was also shown.
ISSN:1678-7064