Phosphorylation of TRIM28 Enhances the Expression of IFN-β and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells

Phosphorylation of TRIM28 Enhances the Expression of IFN-β and Proinflammatory Cytokines During HPAIV Infection of Human Lung Epithelial Cells

Human infection with highly pathogenic avian influenza viruses (HPAIV) is often associated with severe tissue damage due to hyperinduction of interferons and proinflammatory cytokines. The reasons for this excessive cytokine expression are still incompletely understood, which has hampered the develo...

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Bibliographic Details
Main Authors: Tim Krischuns, Franziska Günl, Lea Henschel, Marco Binder, Joschka Willemsen, Sebastian Schloer, Ursula Rescher, Vanessa Gerlt, Gert Zimmer, Carolin Nordhoff, Stephan Ludwig, Linda Brunotte
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Immunology
Subjects:
influenza
TRIM28
KAP1
TIF1-beta
innate immunity
IFN-β
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02229/full

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https://www.frontiersin.org/article/10.3389/fimmu.2018.02229/full

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