Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair.

Heterochromatin delays CRISPR-Cas9 mutagenesis but does not influence the outcome of mutagenic DNA repair.

Genome editing occurs in the context of chromatin, which is heterogeneous in structure and function across the genome. Chromatin heterogeneity is thought to affect genome editing efficiency, but this has been challenging to quantify due to the presence of confounding variables. Here, we develop a me...

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Bibliographic Details
Main Authors: Eirini M Kallimasioti-Pazi, Keerthi Thelakkad Chathoth, Gillian C Taylor, Alison Meynert, Tracy Ballinger, Martijn J E Kelder, Sébastien Lalevée, Ildem Sanli, Robert Feil, Andrew J Wood
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-12-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.2005595

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https://doi.org/10.1371/journal.pbio.2005595

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