Rutaecarpine Increases Nitric Oxide Synthesis via eNOS Phosphorylation by TRPV1-Dependent CaMKII and CaMKKβ/AMPK Signaling Pathway in Human Endothelial Cells

Rutaecarpine Increases Nitric Oxide Synthesis via eNOS Phosphorylation by TRPV1-Dependent CaMKII and CaMKKβ/AMPK Signaling Pathway in Human Endothelial Cells

Rutaecarpine (RUT) is a bioactive alkaloid isolated from the fruit of <i>Evodia rutaecarpa</i> that exerts a cellular protective effect. However, its protective effects on endothelial cells and its mechanism of action are still unclear. In this study, we demonstrated the effects of RUT o...

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Bibliographic Details
Main Authors: Gi Ho Lee, Chae Yeon Kim, Chuanfeng Zheng, Sun Woo Jin, Ji Yeon Kim, Seung Yeon Lee, Mi Yeon Kim, Eun Hee Han, Yong Pil Hwang, Hye Gwang Jeong
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:International Journal of Molecular Sciences
Subjects:
rutaecarpine
eNOS
AMPK
CaMKII
Ca<sup>2+</sup>
TRPV1
Online Access:https://www.mdpi.com/1422-0067/22/17/9407

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