Otx2 and Oct4 Drive Early Enhancer Activation during Embryonic Stem Cell Transition from Naive Pluripotency

Embryonic stem cells (ESCs) are unique in that they have the capacity to differentiate into all of the cell types in the body. We know a lot about the complex transcriptional control circuits that maintain the naive pluripotent state under self-renewing conditions but comparatively less about how ce...

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Bibliographic Details
Main Authors: Shen-Hsi Yang, Tüzer Kalkan, Claire Morissroe, Hendrik Marks, Hendrik Stunnenberg, Austin Smith, Andrew D. Sharrocks
Format: Article
Language:English
Published: Elsevier 2014-06-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714004318