Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation

Tibetan adaptation to the high-altitude environment represents a case of natural selection during recent human evolution. Here the authors investigated the chromatin and transcriptional landscape of umbilical endothelial cells from Tibetan and Han Chinese donors and provide genome-wide characterizat...

Full description

Bibliographic Details
Main Authors:	Jingxue Xin, Hui Zhang, Yaoxi He, Zhana Duren, Caijuan Bai, Lang Chen, Xin Luo, Dong-Sheng Yan, Chaoyu Zhang, Xiang Zhu, Qiuyue Yuan, Zhanying Feng, Chaoying Cui, Xuebin Qi, Ouzhuluobu, Wing Hung Wong, Yong Wang, Bing Su
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-10-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-18638-8

id	doaj-5d727e2e509d4204b777b2789c0541c6
record_format	Article
spelling	doaj-5d727e2e509d4204b777b2789c0541c62021-10-03T11:51:54ZengNature Publishing GroupNature Communications2041-17232020-10-0111112010.1038/s41467-020-18638-8Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptationJingxue Xin0Hui Zhang1Yaoxi He2Zhana Duren3Caijuan Bai4Lang Chen5Xin Luo6Dong-Sheng Yan7Chaoyu Zhang8Xiang Zhu9Qiuyue Yuan10Zhanying Feng11Chaoying Cui12Xuebin Qi13Ouzhuluobu14Wing Hung Wong15Yong Wang16Bing Su17State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesDepartments of Statistics, Stanford UniversityHigh Altitude Medical Research Center, School of Medicine, Tibetan UniversityCEMS, NCMIS, MDIS, Academy of Mathematics and Systems Science, Chinese Academy of SciencesState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesSchool of Mathematical Science, Inner Mongolia UniversityCEMS, NCMIS, MDIS, Academy of Mathematics and Systems Science, Chinese Academy of SciencesDepartments of Statistics, Stanford UniversityCEMS, NCMIS, MDIS, Academy of Mathematics and Systems Science, Chinese Academy of SciencesCEMS, NCMIS, MDIS, Academy of Mathematics and Systems Science, Chinese Academy of SciencesHigh Altitude Medical Research Center, School of Medicine, Tibetan UniversityState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesHigh Altitude Medical Research Center, School of Medicine, Tibetan UniversityBio-X Program, Stanford UniversityCEMS, NCMIS, MDIS, Academy of Mathematics and Systems Science, Chinese Academy of SciencesState Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of SciencesTibetan adaptation to the high-altitude environment represents a case of natural selection during recent human evolution. Here the authors investigated the chromatin and transcriptional landscape of umbilical endothelial cells from Tibetan and Han Chinese donors and provide genome-wide characterization of the hypoxia regulatory network associated high-altitude adaptation.https://doi.org/10.1038/s41467-020-18638-8
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Jingxue Xin Hui Zhang Yaoxi He Zhana Duren Caijuan Bai Lang Chen Xin Luo Dong-Sheng Yan Chaoyu Zhang Xiang Zhu Qiuyue Yuan Zhanying Feng Chaoying Cui Xuebin Qi Ouzhuluobu Wing Hung Wong Yong Wang Bing Su
spellingShingle	Jingxue Xin Hui Zhang Yaoxi He Zhana Duren Caijuan Bai Lang Chen Xin Luo Dong-Sheng Yan Chaoyu Zhang Xiang Zhu Qiuyue Yuan Zhanying Feng Chaoying Cui Xuebin Qi Ouzhuluobu Wing Hung Wong Yong Wang Bing Su Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation Nature Communications
author_facet	Jingxue Xin Hui Zhang Yaoxi He Zhana Duren Caijuan Bai Lang Chen Xin Luo Dong-Sheng Yan Chaoyu Zhang Xiang Zhu Qiuyue Yuan Zhanying Feng Chaoying Cui Xuebin Qi Ouzhuluobu Wing Hung Wong Yong Wang Bing Su
author_sort	Jingxue Xin
title	Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
title_short	Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
title_full	Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
title_fullStr	Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
title_full_unstemmed	Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
title_sort	chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-10-01
description	Tibetan adaptation to the high-altitude environment represents a case of natural selection during recent human evolution. Here the authors investigated the chromatin and transcriptional landscape of umbilical endothelial cells from Tibetan and Han Chinese donors and provide genome-wide characterization of the hypoxia regulatory network associated high-altitude adaptation.
url	https://doi.org/10.1038/s41467-020-18638-8
work_keys_str_mv	AT jingxuexin chromatinaccessibilitylandscapeandregulatorynetworkofhighaltitudehypoxiaadaptation AT huizhang chromatinaccessibilitylandscapeandregulatorynetworkofhighaltitudehypoxiaadaptation AT yaoxihe chromatinaccessibilitylandscapeandregulatorynetworkofhighaltitudehypoxiaadaptation AT zhanaduren chromatinaccessibilitylandscapeandregulatorynetworkofhighaltitudehypoxiaadaptation AT caijuanbai chromatinaccessibilitylandscapeandregulatorynetworkofhighaltitudehypoxiaadaptation AT langchen chromatinaccessibilitylandscapeandregulatorynetworkofhighaltitudehypoxiaadaptation AT xinluo chromatinaccessibilitylandscapeandregulatorynetworkofhighaltitudehypoxiaadaptation AT dongshengyan chromatinaccessibilitylandscapeandregulatorynetworkofhighaltitudehypoxiaadaptation AT chaoyuzhang chromatinaccessibilitylandscapeandregulatorynetworkofhighaltitudehypoxiaadaptation AT xiangzhu chromatinaccessibilitylandscapeandregulatorynetworkofhighaltitudehypoxiaadaptation AT qiuyueyuan chromatinaccessibilitylandscapeandregulatorynetworkofhighaltitudehypoxiaadaptation AT zhanyingfeng chromatinaccessibilitylandscapeandregulatorynetworkofhighaltitudehypoxiaadaptation AT chaoyingcui chromatinaccessibilitylandscapeandregulatorynetworkofhighaltitudehypoxiaadaptation AT xuebinqi chromatinaccessibilitylandscapeandregulatorynetworkofhighaltitudehypoxiaadaptation AT ouzhuluobu chromatinaccessibilitylandscapeandregulatorynetworkofhighaltitudehypoxiaadaptation AT winghungwong chromatinaccessibilitylandscapeandregulatorynetworkofhighaltitudehypoxiaadaptation AT yongwang chromatinaccessibilitylandscapeandregulatorynetworkofhighaltitudehypoxiaadaptation AT bingsu chromatinaccessibilitylandscapeandregulatorynetworkofhighaltitudehypoxiaadaptation
_version_	1716845117721018368

Chromatin accessibility landscape and regulatory network of high-altitude hypoxia adaptation

Similar Items