Adaptation Modulates Spike-Phase Coupling Tuning Curve in the Rat Primary Auditory Cortex

• Main Authors: Mohammad Zarei, Mohsen Parto Dezfouli, Mehran Jahed, Mohammad Reza Daliri
• Format: Article
• Language: English
• Published: Frontiers Media S.A. 2020-08-01
• Series: Frontiers in Systems Neuroscience
• Subjects: neural adaptation; spike-LFP coupling; auditory cortex; sensory coding; tuning curve
• Online Access: https://www.frontiersin.org/article/10.3389/fnsys.2020.00055/full

Adaptation is an important mechanism that causes a decrease in the neural response both in terms of local field potentials (LFP) and spiking activity. We previously showed this reduction effect in the tuning curve of the primary auditory cortex. Moreover, we revealed that a repeated stimulus reduces the neural response in terms of spike-phase coupling (SPC). In the current study, we examined the effect of adaptation on the SPC tuning curve. To this end, employing the phase-locking value (PLV) method, we estimated the spike-LFP coupling. The data was obtained by a simultaneous recording from four single-electrodes in the primary auditory cortex of 15 rats. We first investigated whether the neural system may use spike-LFP phase coupling in the primary auditory cortex to encode sensory information. Secondly, we investigated the effect of adaptation on this potential SPC tuning. Our data showed that the coupling between spikes’ times and the LFP phase in beta oscillations represents sensory information (different stimulus frequencies), with an inverted bell-shaped tuning curve. Furthermore, we showed that adaptation to a specific frequency modulates SPC tuning curve of the adapter and its neighboring frequencies. These findings could be useful for interpretation of feature representation in terms of SPC and the underlying neural mechanism of adaptation.