One-Pot-Multicomponent Synthesis of 2,6-Diamino-4-arylpyridine-3,5-dicarbonitrile Derivatives Using Nanomagnetic Fe₃O₄@SiO₂@ZnCl₂

• Main Authors: Behrooz Maleki, Hadi Natheghi, Vahid Sokhanvaran, Samaneh Sedigh Ashrafi
• Format: Article
• Language: English
• Published: Universitas Gadjah Mada 2018-11-01
• Series: Indonesian Journal of Chemistry
• Subjects: 2,6-diamino-4-arylpyridine-3,5-dicarbonitriles; nano magnetic Fe3O4@SiO2@ZnCl2; green chemistry; multi-component reaction
• Online Access: https://jurnal.ugm.ac.id/ijc/article/view/33062
• ISSN: 1411-9420; 2460-1578

Nanomagnetic Fe3O4@SiO2@ZnCl2 was used as a simple, cost-effective, and reusable heterogeneous catalyst for the synthesis of 2,6-diamino-4-arylpyridine-3,5-dicarbonitriles by a one-pot-three-component condensation reaction of malononitrile, ammonium acetate, and aldehydes under solvent-free conditions at 110 °C. Simple and mild reaction conditions, facile preparation of the catalyst, the use of a cheap catalyst and easy workup and isolation are notable features of this method.