The effect of down-regulation of Smad3 by RNAi on hepatic stellate cells and a carbon tetrachloride-induced rat model of hepatic fibrosis

The effect of down-regulation of Smad3 by RNAi on hepatic stellate cells and a carbon tetrachloride-induced rat model of hepatic fibrosis

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Searching for effective Smad3 gene-based gene therapies for hepatic fibrosis, we constructed siRNA expression plasmids targeting the rat Smad3 gene and then delivered these plasmids into hepatic stellate cells (HSCs). The effect of siRNAs on the mRNA levels of Smad2, Smad3, Smad4, and collagens I-&a...

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Bibliographic Details
Main Authors: Z.R. Wang, J.H. Wang, C.L. Hu, W.G. Cao, X.J. Shen, M.Y. Wu, L. Shen, S.L. Wu
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2011-02-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Smad3
SiRNA
Hepatic fibrosis
Carbon tetrachloride
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2011000200002

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