tBRD-1 selectively controls gene activity in the Drosophila testis and interacts with two new members of the bromodomain and extra-terminal (BET) family.

tBRD-1 selectively controls gene activity in the Drosophila testis and interacts with two new members of the bromodomain and extra-terminal (BET) family.

Multicellular organisms have evolved specialized mechanisms to control transcription in a spatial and temporal manner. Gene activation is tightly linked to histone acetylation on lysine residues that can be recognized by bromodomains. Previously, the testis-specifically expressed bromodomain protein...

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Bibliographic Details
Main Authors: Ina Theofel, Marek Bartkuhn, Tim Hundertmark, Thomas Boettger, Stefanie M K Gärtner, Katja Leser, Stephan Awe, Michael Schipper, Renate Renkawitz-Pohl, Christina Rathke
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4177214?pdf=render

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