A concise and practical stereoselective synthesis of ipragliflozin L-proline

A concise and practical stereoselective synthesis of ipragliflozin L-proline

A concise and practical stereoselective synthesis of ipragliflozin L-proline was presented starting from 2-[(5-iodo-2-fluorophenyl)methyl]-1-benzothiophene and 2,3,4,6-tetra-O-pivaloyl-α-D-glucopyranosyl bromide without catalyst via iodine–lithium–zinc exchange. The overall yield was 52% in three st...

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Bibliographic Details
Main Authors:	Shuai Ma, Zhenren Liu, Jing Pan, Shunli Zhang, Weicheng Zhou
Format:	Article
Language:	English
Published:	Beilstein-Institut 2017-06-01
Series:	Beilstein Journal of Organic Chemistry
Subjects:	arylzinc derivative β-C-arylglucoside diastereomer impurity ipragliflozin L-proline stereoselective synthesis
Online Access:	https://doi.org/10.3762/bjoc.13.105

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