Induced pluripotent stem cells derived from one 70-years-old male donor with the APOE-ε4/ε4 alleles
Apolipoprotein E (ApoE) is a lipid-binding protein with ε2, ε3, and ε4 allelic variants in human. The ε4 isoform (ApoE4) is the strongest genetic risk factor for the late-onset form of Alzheimer’s disease (AD), and is also associated with multiple neurological disorders, multiple sclerosis, and cere...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-05-01
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| Series: | Stem Cell Research |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1873506121002415 |
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doaj-5d4389409a254dfe8a7c516b180cf7cd |
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Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jin Wang Xin Liu Xiaofeng Du Zhenhuan Ma Boxin Liu Ruiyun Guo Baofeng Feng Jun Ma Huixian Cui |
| spellingShingle |
Jin Wang Xin Liu Xiaofeng Du Zhenhuan Ma Boxin Liu Ruiyun Guo Baofeng Feng Jun Ma Huixian Cui Induced pluripotent stem cells derived from one 70-years-old male donor with the APOE-ε4/ε4 alleles Stem Cell Research |
| author_facet |
Jin Wang Xin Liu Xiaofeng Du Zhenhuan Ma Boxin Liu Ruiyun Guo Baofeng Feng Jun Ma Huixian Cui |
| author_sort |
Jin Wang |
| title |
Induced pluripotent stem cells derived from one 70-years-old male donor with the APOE-ε4/ε4 alleles |
| title_short |
Induced pluripotent stem cells derived from one 70-years-old male donor with the APOE-ε4/ε4 alleles |
| title_full |
Induced pluripotent stem cells derived from one 70-years-old male donor with the APOE-ε4/ε4 alleles |
| title_fullStr |
Induced pluripotent stem cells derived from one 70-years-old male donor with the APOE-ε4/ε4 alleles |
| title_full_unstemmed |
Induced pluripotent stem cells derived from one 70-years-old male donor with the APOE-ε4/ε4 alleles |
| title_sort |
induced pluripotent stem cells derived from one 70-years-old male donor with the apoe-ε4/ε4 alleles |
| publisher |
Elsevier |
| series |
Stem Cell Research |
| issn |
1873-5061 |
| publishDate |
2021-05-01 |
| description |
Apolipoprotein E (ApoE) is a lipid-binding protein with ε2, ε3, and ε4 allelic variants in human. The ε4 isoform (ApoE4) is the strongest genetic risk factor for the late-onset form of Alzheimer’s disease (AD), and is also associated with multiple neurological disorders, multiple sclerosis, and cerebrovascular disease. Here, induced pluripotent stem cells were derived from the peripheral blood mononuclear cells of a 70-year-old male donor with APOE-ε4/ε4 alleles background to explore pathogenesis and screen potential treatment methods in neurodegenerative diseases. In the newly-developed induced pluripotent stem cell line, the pluripotent markers were well expressed. In addition, the generated cells displayed a normal karyotype and have differentiation potential. |
| url |
http://www.sciencedirect.com/science/article/pii/S1873506121002415 |
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doaj-5d4389409a254dfe8a7c516b180cf7cd2021-05-30T04:41:58ZengElsevierStem Cell Research1873-50612021-05-0153102395Induced pluripotent stem cells derived from one 70-years-old male donor with the APOE-ε4/ε4 allelesJin Wang0Xin Liu1Xiaofeng Du2Zhenhuan Ma3Boxin Liu4Ruiyun Guo5Baofeng Feng6Jun Ma7Huixian Cui8Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; The Second Hospital of Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; The Second Hospital of Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, ChinaHebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China; Human Anatomy Department, Hebei Medical University, Hebei Province 050017, China; Corresponding authors at: Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China. Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China.Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China; Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China; Human Anatomy Department, Hebei Medical University, Hebei Province 050017, China; Corresponding authors at: Hebei Medical University-National University of Ireland Galway Stem Cell Research Center, Hebei Medical University, Hebei Province 050017, China. Hebei Research Center for Stem Cell Medical Translational Engineering, Hebei Province 050017, China.Apolipoprotein E (ApoE) is a lipid-binding protein with ε2, ε3, and ε4 allelic variants in human. The ε4 isoform (ApoE4) is the strongest genetic risk factor for the late-onset form of Alzheimer’s disease (AD), and is also associated with multiple neurological disorders, multiple sclerosis, and cerebrovascular disease. Here, induced pluripotent stem cells were derived from the peripheral blood mononuclear cells of a 70-year-old male donor with APOE-ε4/ε4 alleles background to explore pathogenesis and screen potential treatment methods in neurodegenerative diseases. In the newly-developed induced pluripotent stem cell line, the pluripotent markers were well expressed. In addition, the generated cells displayed a normal karyotype and have differentiation potential.http://www.sciencedirect.com/science/article/pii/S1873506121002415 |