C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors

C-2 phenyl replacements to obtain potent quinoline-based Staphylococcus aureus NorA inhibitors

NorA is the most studied efflux pump of Staphylococcus aureus and is responsible for high level resistance towards fluoroquinolone drugs. Although along the years many NorA efflux pump inhibitors (EPIs) have been reported, poor information is available about structure-activity relationship (SAR) aro...

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Bibliographic Details
Main Authors: Tommaso Felicetti, Gianmarco Mangiaterra, Rolando Cannalire, Nicholas Cedraro, Donatella Pietrella, Andrea Astolfi, Serena Massari, Oriana Tabarrini, Giuseppe Manfroni, Maria Letizia Barreca, Violetta Cecchetti, Francesca Biavasco, Stefano Sabatini
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
antimicrobial resistance breakers
efflux pump inhibitors
nora
staphylococcus aureus
antimicrobial resistance
Online Access:http://dx.doi.org/10.1080/14756366.2020.1719083

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