Impact of ex vivo Sample Handling on DNA Methylation Profiles in Human Cord Blood and Neonatal Dried Blood Spots

Impact of ex vivo Sample Handling on DNA Methylation Profiles in Human Cord Blood and Neonatal Dried Blood Spots

The profiling of DNA methylation modifications in peripheral blood has significant potential to determine risk factors for human disease. Little is known concerning the sensitivity of DNA methylation profiles to ex vivo sample handling. Here, we studied typical conditions prior to sample storage ass...

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Bibliographic Details
Main Authors: Aya Sasaki, Bona Kim, Kellie E. Murphy, Stephen G. Matthews
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Genetics
Subjects:
DNA methylation
cord blood
blood cards
ex vivo storage
reduced representation bisulfite sequencing
Online Access:https://www.frontiersin.org/article/10.3389/fgene.2020.00224/full

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