Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation

Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation

Abstract The phospholamban (PLN) p.Arg14del mutation causes dilated cardiomyopathy, with the molecular disease mechanisms incompletely understood. Patient dermal fibroblasts were reprogrammed to hiPSC, isogenic controls were established by CRISPR/Cas9, and cardiomyocytes were differentiated. Mutant...

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Bibliographic Details
Main Authors: Friederike Cuello, Anika E Knaust, Umber Saleem, Malte Loos, Janice Raabe, Diogo Mosqueira, Sandra Laufer, Michaela Schweizer, Petra van derKraak, Frederik Flenner, Bärbel M Ulmer, Ingke Braren, Xiaoke Yin, Konstantinos Theofilatos, Jorge Ruiz‐Orera, Giannino Patone, Birgit Klampe, Thomas Schulze, Angelika Piasecki, Yigal Pinto, Aryan Vink, Norbert Hübner, Sian Harding, Manuel Mayr, Chris Denning, Thomas Eschenhagen, Arne Hansen
Format: Article
Language:English
Published: Wiley 2021-06-01
Series:EMBO Molecular Medicine
Subjects:
endoplasmic reticulum
engineered heart tissue
human‐induced pluripotent stem cells
mitochondria
phospholamban p.Arg14del
Online Access:https://doi.org/10.15252/emmm.202013074

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