Downregulation of Calcineurin Gene Is Associated with Glucantime(®) Resiatance in Leishmania infantum

Downregulation of Calcineurin Gene Is Associated with Glucantime(®) Resiatance in Leishmania infantum

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  Background: Pentavalent antimonials are the first line drugs for the treatment of leishmaniasis. Unresponsiveness of Leishmania spp. to antimonial drugs is a serious problem in some endemic areas. Investigations on molecular mechanisms involved in drug resistance are essential for monitoring an...

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Bibliographic Details
Main Authors: Mohammad Bagher Khadem Erfan, Mehdi Mohebali, Elham Kazemi-Rad, Homa Hajjaran, Gholamhossein Edrissian, Setareh Mamishi, Mojtaba Saffari, Reza Raoofian, Mansour Heidari
Format: Article
Language:English
Published: Tehran University of Medical Sciences 2013-09-01
Series:Iranian Journal of Parasitology
Subjects:
Antimonial resistance
Calcineurin gene
Leishmania infantum
Real-time RT-PCR
cDNA-AFLP
Online Access:https://ijpa.tums.ac.ir/index.php/ijpa/article/view/483
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